Dumeaux, Vanessa; Kringen, Pedro; Wang, Yun; Nesland, Jahn M.; Kristensen, Gunnar; Børresen - Dale, Anne - Lise; Dørum, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2005-10-17)
Background: Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder
mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic
mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline status, TP53 status, survival
and age at diagnosis, as previous studies have not been conclusive.
Methods: ...